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TMPRSS4与肿瘤侵袭转移的关系 被引量：1

Relationship between TMPRSS4 and tumor invasion and metastasis
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摘要 Ⅱ型跨膜丝氨酸蛋白酶4（TMPRSS4）是一种新发现的Ⅱ型跨膜丝氨酸蛋白，目前研究发现它的表达与肿瘤的侵袭转移存在相关性，但具体作用机制目前尚不明确。本文就其基本结构、生物学功能及其在肿瘤侵袭转移方面的作用和机制作一综述。 Type Ⅱ transmembrane serine proteases 4 （TMPRSS4） is a novel type Ⅱ transmembrane serine pro-tease. Present study showed that its expression was related with tumor invasion and metastasis, although its onco-genic significance and molecular mechanisms are still unknown. In this review, the author try to introduce its struc-ture, biological function and mechanism in tumor invasion and metastasis.
作者 王宇翔 何新阳 梁伟 姚寒晖 张传海 管佳佳
机构地区 安徽医科大学附属省立医院胃肠外科
出处 《国际外科学杂志》 2013年第7期478-481,共4页 International Journal of Surgery
基金 国家自然科学基金（No.81101877） 安徽省卫生厅医学科研课题（No.13ZC011）
关键词 Ⅱ型跨膜丝氨酸蛋白酶4 上皮间质转化 侵袭转移 肿瘤转移 生物学 丝氨酸蛋白酶类 TMPRSS4 EMT Invasion Neoplasm metastasis Biology Serine proteases
分类号 R730 [医药卫生—肿瘤]
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参考文献29

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二级参考文献26

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国际外科学杂志
2013年 第7期

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