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MicroRNA与肿瘤糖代谢研究进展 被引量：2

Research progress in microRNA regulation of tumor glucose metabo-lism
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摘要 有氧糖酵解（Warburg效应）是肿瘤细胞的重要特征，它是癌基因和抑癌基因共同作用的结果。microRNA（miRNA）能够在转录后水平参与这些癌基因和抑癌基因的表达来调控肿瘤糖代谢方式的转变。对miRNA调控糖代谢机制的深入研究能够提供新的肿瘤治疗策略。 Aerobic glycolysis ,which is also termed as Warburg effect,is one of the most common and profound biochemical phenotypes of tumor cells. Several oncogenes and tumor suppressors genes have been implicated in aer-obic glycolysis. MieroRNAs can control this metabolic switch by regulating oncogenes and tumor suppressors genes in a post-transcriptional way. A deeper understanding of the mechanisms and pathways by which miRNAs regulate the aerobic glyeolysis will hopefully lead to a new therapeutic strategy for malignant cancer.
作者 胡骏 殷保兵
机构地区 复旦大学附属华山医院普外科
出处 《国际外科学杂志》 2013年第7期489-492,共4页 International Journal of Surgery
关键词 糖代谢 糖酵解 MICRO RNAS 肿瘤 Glucose Metabolism Glycolysis MicroRNAs Neoplasms
分类号 R730.2 [医药卫生—肿瘤]
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参考文献30

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同被引文献40

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国际外科学杂志
2013年 第7期

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