摘要
目的:观察金威消石颗粒对大鼠胆汁分泌量及胆汁脂质含量的影响。方法:健康雄性大鼠60只,随机分为空白对照组,阳性对照组,金威消石颗粒低、中、高剂量组,分别经胃灌注蒸馏水、消炎利胆片、不同剂量的金威消石颗粒,每日1次,连续21天。通过胆总管造瘘引流胆汁,检测各组灌注前1小时内及灌注后4小时内每小时的胆汁流量,并测定灌注前1小时及灌注后1小时内所引流胆汁中总胆固醇(TC)和甘油三酯(TG)的含量。结果:金威消石颗粒中、高剂量组灌注后1小时内大鼠胆汁流量明显高于空白对照组(P<0.05);各剂量组灌注前1小时及灌注后1小时内大鼠胆汁中TC含量均明显低于空白对照组(P<0.05);各剂量组灌注后1小时内胆汁中TC含量明显低于灌注前1小时(P<0.05)。结论:金威消石颗粒具有利胆作用,且可明显降低大鼠胆汁中胆固醇含量,有助于抑制胆囊内胆固醇结石的形成。
Objective:To explore the effects of jinwei xiaoshi granule on rats biliation and lipid content in bile.Methods:Sixty healthy rats were randomly divided into blank control,positive and jinwei xiaoshi granule low,middle and high dose groups,each group was given distilled water,xiaoyan lidan tablet and different dose jinwei xiaoshi granule,once a day for 21 days,bile was drained by common bile duct fistula operation,bile flow volume was determined within 1 hour before perfusion and within 4 hours after perfusion,the TC and TG contents of bile were determined 1hour before and after perfusion.Results:Rats’bile flow volume in jinwei xiaoshi granule middle and high dose groups 1hour after perfusion was increased obviously,that was more than that of blank control group(P < 0.05),the TC content of bile in every dose jinwei xiaoshi granule group 1hour before and after perfusion was significantly reduced,that was less than that in blank control group(P < 0.05),the TC content of bile in every dose jinwei xiaoshi granule group 1hour after perfusion was obviously lower than before perfusion(P < 0.05) .Conclusion:Jinwei xiaoshi granule can obviously promote bile excrete and decrease rats’TC content in bile to inhibit the cholesterol stone formation in gallbladder.
出处
《中国中医药科技》
CAS
2013年第4期345-345,437,共2页
Chinese Journal of Traditional Medical Science and Technology
基金
上海市卫生局中医药开发研究基金资助
No.2011XY011
