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Epigenetic Regulation of Serotonin Transporter in Psychiatric Disorders

Epigenetic Regulation of Serotonin Transporter in Psychiatric Disorders
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摘要 SLC6A4 （solute carrier family 6, member 4） gene encodes a serotonin transporter （5-hydroxytryptamine transporter, HTT）, which transports synaptic serotonin into presynaptic terminal. SLC6A4 is known to be the target of antidepressants such as selective serotonin reuptake inhibitors （SSRIs）. Inhibition of HTT increases synaptic serotonin concentration and thereby exerts antidepressant efficacy. A large number of genetic studies suggest the contribution of genetic variations of SLC6A4 to various psychiatric disorders. The most studied genetic variation, HTT-linked polymorphic region （HTTLPR）, SLC6A4 （solute carrier family 6, member 4） gene encodes a serotonin transporter （5-hydroxytryptamine transporter, HTT）, which transports synaptic serotonin into presynaptic terminal. SLC6A4 is known to be the target of antidepressants such as selective serotonin reuptake inhibitors （SSRIs）. Inhibition of HTT increases synaptic serotonin concentration and thereby exerts antidepressant efficacy. A large number of genetic studies suggest the contribution of genetic variations of SLC6A4 to various psychiatric disorders. The most studied genetic variation, HTT-linked polymorphic region （HTTLPR）,
作者 Hiroko Sugawara Miki Bundo Jun Ishigooka Kazuya Iwamoto Tadafumi Kato
机构地区 Laboratory for Molecular Dynamics of Mental Disorders Department of Psychiatry Department of Molecular Psychiatry Department of Psychiatry.Tokyo Women's Medical University
出处 《Journal of Genetics and Genomics》 SCIE CAS CSCD 2013年第7期325-329,共5页 遗传学报（英文版）
关键词 SLC Epigenetic Regulation of Serotonin Transporter in Psychiatric Disorders
分类号 R749 [医药卫生—神经病学与精神病学]
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Journal of Genetics and Genomics
2013年 第7期

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