利奈唑胺对老年重症感染患者血乳酸水平的影响

Effect of linezolid on blood lactic acid during treatment of elder patients with severe infection

目的观察利奈唑胺对老年重症感染患者血乳酸(BLA)水平的影响。方法回顾分析31例老年重症感染患者资料,23例予利奈唑胺治疗,8例予万古霉素治疗,疗程均为14d。观察并比较治疗及停药过程中BLA水平的变化。结果使用利奈唑胺的患者95.65%在治疗期间发生高乳酸血症(BLA≥2mmol/L),随疗程的增加BLA逐渐升高,停用利奈唑胺1周后逐渐降至治疗前水平;高乳酸血症不影响患者预后。使用万古霉素的患者未发生BLA升高。结论使用利奈唑胺治疗的老年重症感染患者BLA轻度升高,停药后可恢复至用药前水平,对预后无明显影响。

Objective To evaluate the effect of linezolid on blood lactic acid（BLA） in the process of treating elder patients with severe infection.Methods The clinical data of 31 elder patients with severe infection were retrospectively analyzed,of whom 23 cases（group A） were treated with linezolid and 8 cases（group B） were treated with vancomycin for 14 days.The changes of BLA levels were observed and compared between two groups.Results The incidence rate of hyperlactatemia（BLA≥2 mmol/L） was 95.65% in group A and zero in group B.In group A,BLA level was gradually increased as the treatment went on,which returned to the baseline in a week after linezolid withdrawal.Hyperlactatemia did not affect the prognosis.Conclusion Linezolid treatment may produce a mild increase of BLA level in the elderly with severe infection,which returns to the baseline and does not affect the prognosis.