β-受体在婴幼儿血管瘤组织中的表达及意义

The significance of beta-receptor expression in infantile hemangiomas

目的探讨β受体在婴幼儿血管瘤组织中的表达及意义。方法采用免疫组织化学SP法，检测40例婴幼儿血管瘤（实验组）、20例静脉畸形及10例正常皮肤（阴性对照组）标本组织中β受体的表达。结果40例婴幼儿血管瘤中仅在28例标本中见β2受体呈阳性表达，阳性表达率70％（28／40），β1受体未见表达；28例阳性标本中24例为增殖期，4例为非增殖期，婴幼儿血管瘤与静脉畸形、正常皮肤组织β2受体阳性表达比较，差异有统计学意义，β2受体在增殖期与消退期的阳性表达比较，差异有统计学意义（P〈0．05）。20例静脉畸形及10例正常皮肤组织中未见β1受体表达。结论β2受体特异表达于婴幼儿血管瘤，且高表达于增殖期。

Objective To investigate the expression and significance of beta-receptor （β-R） in infantile hemangioma. Methods The expression of β-R was detected by immunohistochemistry in infantile hemangioma（40 cases） , venous malformation （ 20 cases） and normal skin （ 10 cases）. Results The positive expression rate of β2-R was 70% （28/40） in infantile hemangioma, while no expression of β2-R in venous malformation and normal skin. Among 28 cases with positive expression of β2-R, 24 cases were in proliferative phase. The positive expression of β2-R in infantile hamangioma was significantly higher than that in venous malformation and normal skin tissue. The positive expression of β2-R in the proliferative hemangioma and non-proliferative hemangioma was also significantly different（ P 〈 0.05 ）. Conclusions β2-R is specifically expressed in infantile hemangioma, especially in proliferative hemangioma.