金丝带缩酚酸类化学成分研究

Study on the Depside Derivatives of Lethariella zahlbruckneri(Dr.) Krog.

对采自青海省的金丝带[Lethariella zahlbruckneri(Dr.)Krog.]的乙酸乙酯部分进行研究,采用硅胶柱色谱、半制备高效液相和重结晶技术进行分离纯化,通过1 H-NMR、13 C-NMR技术对化合物结构进行鉴定,结果共分离鉴定了5个化合物,包括:1个缩酚酸类:雪茶素(5);4个缩酚酸和缩酚酸环醚裂解产物:赤星衣酸甲酯(1),β-苔黑酚酸甲酯(2),苔色酸甲酯(3)和苔色酸乙酯(4)。其中化合物1、3、4、5均为首次从该植物中分得。

The chemical constitutes of the EtOAc fraction from Lethariella zahlbruckneri （Dr.） Krog.,collected from Qinghai Province,were studied.Five compounds were isolated by repeated gel column chromatography,semi-prepared HPLC and re-crystallization.Their structures were characterized by 1H-NMR and 13C-NMR.Compound 5 is vermicularin,belongs to depsides;Compound 1 is Methyl haematommate;Compound 2 is methyl β-orcinolcarboxylate;Compound 3 is methyl orsellinate;Compound 4 is ethyl orsellinate;The above four compounds all belong to cleavage products of depsides and depsidones.Compounds 1 , 3 , 4 , 5 were isolated from L.zahlbruckneri for the first time.