我国人群GJB2基因235delC突变与非综合征性耳聋相关性的meta分析

Meta-analysis for association between GJB2 gene 235delC mutation and risk for non-syndromic hearing loss in Chinese population

目的探讨我国人群GJB2基因235delC突变与非综合征性耳聋的相关性。方法采用固定效应模型对国内外公开发表的中国人群GJB2基因235delC突变与非综合征性耳聋患者相关性的病例对照研究进行meta分析。结果该meta分析共纳人文献22篇。合并效应量：OR=11.375（ Z=16.34,P=0.00,95%可信区间为8.497 - 15.227）。异质性检验：χ^2=21.95, P=0.142, I^2=24.9%。出版偏倚：Z=0.70, P=0.481。结论GJB2基因235delC突变是导致NSHL的重要危险因子,在新生儿听力筛查中应重视该基因突变的检测。

Objective To investigate the association between GJB2 gene 235delC mutation and risk for non-syndromic hearing loss （NSHL） in Chinese population. Methods To perform a meta-analysis with fixed-effect modelon published casecontrol study addressing association between GJB2 gene 235delC mutation and risk for non-syndromic hearing loss in Chinese population. Results A total of 22 articles were included in the meta-analysis.The pooled OR=11.375 （Z=16.34,P=0.00,95% confidence interval： 8.497-15.227）. Heterogeneity test： χ2=27.95,P=0.142, I2=24.9%. Publication bias test： Z=0.70,P=0.481. Conclusion GJB2 gene 235delC mutation is a veryimportant risk factor for the development of NSHL. Great attention should be paid on GJB2 gene 235delC mutationscreening for the purpose of preventing NSHL in Chinese population.