子痫前期孕妇血清氧化型低密度脂蛋白检测及临床意义

Detection and clinical significances of serous oxidized lowdensity lipoprotein in preeclampsia

目的检测子痫前期孕妇血清氧化低密度脂蛋白(oxLDL)并研究其临床意义。方法选择子痫前期孕妇为研究对象(子痫组),以同期正常健康孕妇为对照(对照组),比较两组研究对象常规生化指标、oxLDL和围产期并发症的差异,分析围产期并发症与oxLDL的相关性。结果子痫组和对照组研究对象在FBG、TC、TG、LDL和HDL方面差异无统计学意义(P>0.05),子痫组SBP、DBP和oxLDL显著高于对照组(P<0.05)。子痫组早产、产后出血、新生儿体重异常、胎膜早破和产后感染发生率显著高于对照组(P<0.05)。早产、产后出血、新生儿体重异常、胎膜早破和产后感染与血清oxLDL呈正相关(rs>0,P<0.05)。结论子痫前期孕妇oxLDL显著高于正常孕妇,其水平与围产期并发症密切相关。

Objective To detect the serous oxidized low-density lipoprotein （oxLDL） in preeclampsia and analyze its clinical significances. Methods Pregnant woman with preeclampsia were selected for study,while the healthy pregnant woman were as control group. The serous oxLDL were compared and the correlation between oxLDL and perinatal complications were analyzed. Results The differences in FBG,TC,TG,LDL and HDL were not significant,while the SBP,DBP and oxLDL in preeclampsia were significantly higher than in control group （P 〈 0.05）. The perinatal complications in preeclampsia were significantly higher than in control group （P 〈 0.05）. The oxLDL correlated positively with perinatal complications（rx〉 0,P 〈 0.05）. Conclusion Serous oxLDL in preeclampsia were significantly higher than in healthy pregnant woman,which correlated positively with perinatal complications.