阿托伐他汀对自发性高血压大鼠心肌组织GLUT4表达的影响及意义

Significance and effects of atorvastatin on GLUT4 expression in myocardial tissue of spontaneously hypertensive rats

目的:探讨阿托伐他汀对自发性高血压大鼠(spontaneously hypertensive rats,SHR)心肌组织葡萄糖转运蛋白4(glu-cose transporter-4,GLUT4)表达的影响及其对心肌肥厚的逆转作用与可能机制。方法:将16只8周龄SHR随机分为:阿托伐他汀药物干预组(ATV组,n=8)与SHR模型对照组(SHR组,n=8),以8只同周龄Wistar-Kyoto大鼠作为正常对照(WKY组)。观察阿托伐他汀灌胃10周后大鼠血脂、心肌肥厚指标、GLUT4 mRNA及其蛋白表达的改变。结果:经过10周治疗,ATV组及SHR组血脂水平差异无统计学意义(P>0.05)。ATV组左室重量指数低于SHR组(P<0.05)。在ATV组,GLUT4表达高于SHR组(P<0.05)。结论:阿托伐他汀可上调SHR肥厚心肌组织中GLUT4的表达,有效逆转左室肥厚。

Objective：To investigate the effects of atorvastatin on GLUT4 expression in myocardial tissue of spontaneously hyperten- sive rats（SHR） and its reverse effect and possible mechanism of cardiac hypertrophy. Methods： 16 eight-week-old male spontaneously hypertensive rats were randomly divided into two groups： Group of atorvastatin intervention （ATV,n = 8） , and group of SHR model comparison（ SHR, n = 8）. 8 Wistar-kyoto rats with the same age were served as the normal control （WKY, n = 8）. The groups were intragastric administration by atorvastatin for 10 weeks, and the change of blood lipid, the index of cardiac hypertrophy and GLUT4 mRNA protein expression will be observed. Results： There was not obvious difference of blood lipid level between ATV and SHR group （P 〉0.05） after 10 week＇s treatment. Compared with SHR group, the index of left ventricular mass is lower in ATV group （ P 〈 0.05 ）. The GLUT4 expression of ATV group is higher than SHR group （ P 〈 0.05 ）. Conclusion ： Atorvastatin increases GLUT4 ex- pression in SHR cardiac hypertrophy and effectively reverses left ventricular hypertrophy of spontaneously hypertensive rats.