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T-bet in the spot light： roles in distinct T-cell fate determination 被引量：3

T-bet in the spot light： roles in distinct T-cell fate determination
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摘要 The transcription factor T-bet was originally described to be important for the differentiation of the CD4＋ Thl subset. More recent investigations implicate T-bet in the lineage commitment of a variety of innate immune cells also. The T-bet appears to have a dual role in the immune system. The transcription factor T-bet was originally described to be important for the differentiation of the CD4＋ Thl subset. More recent investigations implicate T-bet in the lineage commitment of a variety of innate immune cells also. The T-bet appears to have a dual role in the immune system.
作者 Sundararajan Jayaraman
机构地区 Department of Surgery
出处 《Cellular & Molecular Immunology》 SCIE CAS CSCD 2013年第4期289-291,共3页 中国免疫学杂志（英文版）
关键词 Innate lymphoid cells T-BET T helper cell subsets Innate lymphoid cells T-bet T helper cell subsets
分类号 S858.31 [农业科学—临床兽医学] TP391.41 [自动化与计算机技术—计算机应用技术]
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参考文献15

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  • 2Bending D, de la Perla H, Veldhoen M, Phillips JM, Uyttenhove C, Stockinger B et al. Highly purified Th17 cells from BDC2.5NOD mice convert into Thl-like cells in NOD/SCID recipient mice. J Clin Invest 2009; 119: 565-572.
  • 3Martin-Orozco N, ChungY, ChangSH, Wang YH, Dong C. Th 17 cells promote pancreatic inflammation but only induce diabetes efficiently in Iymphopenic hosts after conversion into Th 1 cells. Eur J Immunol 2009; 39: 216-224.
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  • 7Hori S, Nomura T, Sakaguchi S. Control of regulatory T cell development by the transcription factor Foxp3. Science 2003; 299: 1057-106l.
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  • 9Rankin LC, Groom JR, Chopin M, Herold MJ, Walker JA, Mielke LA et al. The transcription factor T-bet is essential for the development of NKp46+ innate lymphocytes via the Notch pathway. Nat Immunol 20l3; 14: 389-395.
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同被引文献7

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二级引证文献13

Cellular & Molecular Immunology
2013年 第4期

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