脑梗死后认知功能损害与血尿酸水平关联性研究

Correlation between Cognitive Impairment and Level of Blood Uric Acid in Patients with Cerebral Infarction

目的:评价脑梗死后认知功能损害与血尿酸水平的关联性。方法:纳入脑梗死患者211例,根据蒙特利尔认知评估量表(MoCA)测评判断有无认知损害,比较有(无)认知损伤患者血尿酸水平的差异,同时根据血尿酸水平,进行高尿酸血症患者与非高尿酸血症患者发生认知功能损害的相对危险度评价。结果:无认知损害与有认知损害患者血尿酸水平差异无统计学意义;高尿酸血症患者相对于非高尿酸血症患者发生脑梗死后认知功能损害的相对危险度为1.31,95%CI(1.16,1.47)。结论:脑梗死后存在高尿酸血症患者认知功能损害危险性增高。

Objective： To assess the correlation between cognitive impairment and level of blood uric acid in patients after cerebral infarction. Methods： Two hundred and twenty-one patients with cerebral infarction were enrolled and divided into normal cognitive group and cognitive impairment group according to the scores of Montreal Cognitive Assessment （MoCA）. The difference of blood uric acid between two groups was compared. The relative risk of cognitive impairment in patients with and without hyperuricemia was assessed. Results： There was no significant difference of blood uric acid level between the normal cognitive group and cognitive impairment group. The relative risk of patients with hyperuricemia to those without hyperuricemia was 1.31; and 95% confidence interval was 1.16 to 1.47. Conclusion： Hy- peruricemia increases the risk of cognitive impairment in cerebral infarction patients.