海绵状电正性聚合物微粒的合成以及抗菌性

Synthesis and antibacterial activity of spongelike cationic polymeric particles

以甲基丙烯酸缩水甘油酯(GMA)和甲基丙烯酸甲酯(MMA)为单体、亚甲基双丙烯酰胺(BIS)为交联剂、琥珀酸二异辛酯磺酸钠(DOSS)为乳化剂,通过乳液聚合合成了带环氧结构的纳米聚合物粒子(EPPs)。EPPs与三甲胺盐酸盐反应后制得粒径增大数十倍的海绵状电正性聚合物微粒(CPPs),CPPs的电荷密度用胶体滴定法进行测定,其结构通过红外光谱进行了表征。用烧瓶振荡法研究了CPPs的抗菌性,结果表明,CPPs对大肠杆菌(E.coli)和金黄色葡萄球菌(S.aureus)的抑菌率均超过98.5%。

The epoxy-containing polymeric nanoparticles（EPPs） were synthetized by emulsion polymerization method using glycidyl methacrylate（GMA） and methyl methacrylate（MMA） as monomers,N,N-methylene bis（acrylamide）（BIS） as crosslinker,dioctyl sodium sulfosuccinate（DOSS） as emulsifier.The spongelike cationic polymeric particles（CPPs） were prepared with reaction of EPPs and trimethylamine hydrochloride.The particle size of EPP was increased dozens of times after cationization.The cationic density of CPPs were investigated by colloid titration and the chemical structure of CPP was characterized by FTIR.The antibacterial activity was investigated by shaking-flask method.The results showed that all the CPPs have inhibitory rate over 98.5% against staphylococcus aureus（S.aureus） and escherichia coli（E.coli）.