氟喹诺酮药物不良反应分析及合理应用

Analysis of adverse reaction of fluoroquinolones and reasonable application

目的分析氟喹诺酮类药物的不良反应和合理应用,为临床上提供用药依据。方法选取2010年1月—2013年1月该院使用氟喹诺酮类药物发生不良反应的120例患者,对其不良反应的药物种类、给药途径、临床表现进行分析。结果 120例不良反应涉及5种氟喹诺酮类药物,左氧氟沙星和加替沙星和分别占48例(40.0%)和37例(30.8%),不良反应的发生率明显高于其他药物;静脉给药的不良反应发生率71.7%大于口服给药的28.3%;不良反应共累及人体9个系统,主要是皮肤及其附件不良反应45例(37.5%),其次为胃肠道系统34例(28.3%)和神经系统20例(16.7%)。结论氟喹诺酮类药物易发生不良反应,在临床应用时要密切观察,提高用药的安全性和合理性。

Objective analysis of the fluoroquinolone adverse drug reactions and reasonable application. Methods 120 patients of our hospital use of fluoroquinolones adverse reactions, its analysis of the types of adverse reactions to drugs, route of administration, clinical manifestations. Results levofloxacin processing gatifloxacin and accounted for 48 cases （40.0%） and 37 patients （30.8%）, the incidence of adverse reactions was significantly higher than other drugs; intravenous administration of the incidence of adverse reactions, 71.7% greater than the oral to 28.3% of the drug; adverse reaction involving a total of nine human system. Conclusion fluoroquinolones prone to adverse reactions in the clinical application should be closely observed, and improves safety and rationality.