社区家庭口服酪酸梭菌治疗低出生体重早产儿喂养不耐受疗效分析

Effect of Clostridium Butyricum on Feeding Intolerance in Low Birth Weight Preterm Infants in Community Family

目的:观察在社区家庭中口服酪酸梭菌治疗低出生体重早产儿喂养不耐受的效果,分析其安全性。方法:将50例低出生体重早产儿按随机数表法分为治疗组和对照组各25例,治疗组正常母乳喂养并给予益生菌制剂(口服酪酸梭菌活菌散剂),每次0.5 g,每天2次;对照组仅予母乳喂养。患儿满月(日龄28 d)时比较两组喂养不耐受痊愈率、体重增长情况和不良反应情况。结果:治疗组喂养不耐受痊愈率为88.0%,高于对照组的64.0%;治疗组体重增长达600 g的婴儿比例为92.0%,明显高于对照组的72.0%;治疗组体重增长平均值708.34 g,高于对照组的602.54 g(P<0.05)。益生菌应用过程中未见明显不良反应发生。结论:社区家庭口服酪酸梭菌治疗低出生体重早产儿喂养不耐受,可提高痊愈率,促进患儿体重增长,安全有效。

Objective： To observe the effect of clostridium butyricum on feeding intolerance in preterm infants with low birth weight in community family,and analyze the safety of therapy.Methods： Fifty cases of low birth weight preterm infants were randomly divided into a treatment group and a control group equally.The treatment group was given probiotics（Clostridium Butyricum Powders） 0.5 g,twice a day,while the control group only fed breast milk.Compare the recovery rate of feeding intolerance,weight growth and occurrence of adverse reactions between the two groups when the patients were one month old（28 days old）.Results： The recovery rate of feeding intolerance in the treatment group was 88.0%,which was significantly higher than that in the control group（64.0%）.When infants were one month old,the ratio of growth weight 600 g in the treatment group was 92.0%,which was significantly higher than that in the control group（72.0%）.The average growth in weight of the treatment group was 708.34 g,which was higher than that of the control group（602.54 g）.No adverse effects were observed.Conclusions： Probiotics may reduce the risk of feeding intolerance in low birth weight preterm infants,promote the growth of body weight.The application of probiotic bacteria is safe.