地佐辛与吗啡用于妇产科术后硬膜外镇痛的疗效观察

Dezocine and Morphine for Postoperative Epidural Analgesia Obstetrics and Gynecology Clinical Observation

目的地佐辛和吗啡分别在妇产科术后硬膜外镇痛中的不良反应及效果观察。方法我们选择了2011年5月—2012年7月间收治的ASAⅠ或Ⅱ级妇产科手术患者160例,自愿选择PECA(硬膜外自控镇痛),随机分成两组A组和B组各80例。两组患者均采用硬膜外联合腰麻,术后分别使用吗啡或地佐辛施行硬膜外自控镇痛。分别记录PECA后,于2、3、7、14、24、36、48h视觉评分及不良反应。结果 A组和B组的镇痛效果均可靠,无明显差异,但在不良反应发生率方面,两组间存在明显差异。A组恶心、呕吐、皮肤瘙痒、呼吸抑制、尿潴留发生率分别为3.75%、2.5%、1.25%、1.25%、3.75%,明显低于B组。结论地佐辛镇痛效果确切,不良反应发生率明显低于吗啡。

Objective To observe adverse reaction and effect of dezocine and morphine for postoperative epidural analgesia of obstetrics and gynecology. Methods Chose 160 patients with ASA Ⅰor Ⅱ level of obstetrics and gynecology surgry from May 2011 to July 2012,voluntary chose PECA（epidural controlled analgesia）and randomized into two groups：group A and group B, 80 cases in each group. Two groups were adopted epidural combined lumbar hemp,postoperative respectively used morphine or dezocine epidural controlled analgesia. Recorded and evaluated 2,3,7,14,24,36,48h visual grading and adverse reactions after PECA. Results Analgesic effect of group A and group B were reliable,no obvious difference,but in terms of incidence of adverse reactions,had obviously differences between two groups. Nausea,vomiting, itching,respiratory depression,incidence of urinary retention in group A were 3.75%,2.5%,1.25%,1.25%,1.25%,were lower than that in group B. Conclusion Analgesic effect of dezocine was exact,incidence of adverse reactions was lower than that of morphine.