根除幽门螺杆菌对胃增生性息肉的治疗作用

Therapeutic effect of eradicating Helicobacter pylori on gastric hyperplastic polyps

目的探讨幽门螺杆菌与胃息肉的关系及根除幽门螺杆菌对胃增生性息肉的治疗作用。方法选取2009年1月—2012年3月来该院治疗的胃息肉患者154例,根据胃息肉病理类型分为增生型组、炎性组、胃底腺型组及腺瘤型组,检测患者的幽门螺杆菌,分析幽门螺杆菌感染与不同类型息肉的相关性。对所有患者进行ESD法切除胃息肉,对幽门螺杆菌阳性的患者进行四联根除螺旋杆菌治疗。将清菌后的病人按清菌成功与否分为清菌成功组及清菌失败组,对两组病人进行随访观察,比较两组间息肉复发率有无差异。结果本研究发现154例胃息肉患者中,增生型72例,占46.75%,胃底腺型56例,占36.36%,炎性息肉15例,占9.74%,腺瘤型11例,占7.14%。Hp感染率由高到低依次为炎性>增生型>胃底腺型>腺瘤型。所有患者均完成ESD法息肉切除术,在随访观察中发现增生性息肉成功清除幽门螺杆菌后,明显低于其他病理类型的复发率,且清菌成功组的复发率明显低于清菌失败组。结论幽门螺旋杆菌感染与增生性息肉的发生关系密切,增生性息肉患者根除幽门螺杆菌后,不易复发,根除幽门螺杆菌对胃增生性息肉具有良好的治疗作用。

Objective To investigate the relationship between Helicobacter pylori infection and gastric polyps, therapeutic effect of eradication of Helicobacter pylori on gastric hyperplastic polyps. Methods Chose 154 cases of patients with gastric polyps in our hospital from January 2009 to March 2012, according to the type of gastric polyps pathological, all patients were divided into hyperplasia type group, inflammatory group, fundic gland-type group and the adenoma group, though testing Helicobacter pylori of patients, analysis the correlation of pylori infection and different types of polyps. All patients were ESD resection of gastric polyps, four pylori eradication therapy for Helicobacter pylori-positive patients. Will clear the bacteria of the patients were divided into success at clear bacteria bacteria clear success group and clearing bacteria failure group, follow-up observation of the two groups of patients, the rate of polyp recurrence whether exsit the differences between the two groups. Results The study found that 154 cases of gastric polyps, 72 cases of hyperplasia, accounting for 46.75%, fundic gland 56 cases, accounting for 36.36%, the inflammatory polyps 15 cases, accounting for 9.74%, adenoma in 11 cases, accounting for 7.14%. Hp infection descending order of inflammatory hyperplasia〉 fundic gland adenoma. All patients completed the ESD method polypectomy, hyperplastic polyps found in the follow-up observation successfully cleared Helicobacter pyiori, significantly lower than other pathological types of recurrence rate, and clear bacteria successful group recurrence rate was significantly lower than the clear bacteria failure group. Conclusion Helicobacter pylori infection and closely related to the occurrence and development of hyperplastic polyps, Eradication of Helicobacter pylori in patients with hyperplastic polyps, less recurrence, eradication of Helicobacter pylori on gastric hyperplastic polyps have a good therapeutic effect.