R-卡尼丁的合成和改进

Improved Synthesis of R-carnitine

以环氧氯丙烷为原料合成了 ( R,S) -卡尼丁 ,用二苯甲酰 - L-酒石酸对其进行了拆分 ,对反应和拆分条件进行了优化 ,并用氧化还原法实现了 S-卡尼丁的消旋化 ,使其可以回收利用。

R,S ) carnitine was prepared from epichlorohydrin in four steps and R canitine was prepared by resolution of ( R,S ) carnitine using (-) dibenzoyl L tartaric acid. We designed a simple oxidation reduction procedure to transfer the (S) carnitine to (R,S) carnitine.