氟伐他汀对血脂正常高血压患者的疗效观察

The efficacy of fluvastatin to hypertensives without hyperlipemia

目的:探讨血脂正常高血压患者应用氟伐他汀的临床疗效。方法:选择血脂正常的高血压患者67例,随机分为治疗组(34例)和对照组(33例),两组在常规应用降压药物基础上予以治疗组每晚口服氟伐他汀纳胶囊40 mg,对照组予以安慰剂口服。治疗前及治疗12周后检查血压、身高、体重、心率、血脂、肝肾功能、动脉内皮功能,参数包括内皮素-1(ET-1)和一氧化氮(NO)、踝臂指数(ABI)、肱动脉内径(D)和血流速度(V)、大动脉弹性指数(C1)、小动脉弹性指数(C2),计算肱动脉内径变化率(FMD)。结果:治疗组与对照组相比,治疗组收缩压、脉压差较对照组明显降低;治疗组的FMD,NO明显高于对照组,ET-1显著少于对照组;治疗组的C2,ABI大于对照组。结论:氟伐他汀可降低血脂正常高血压患者的收缩压和脉压差,高血压患者在常规治疗基础上加用他汀类药物可有效改善血管内功能及弹性。

Objective：To investigate the clinical effect of fluvastatin in hypertensives without hyperlipemia. Methods：Sixty- seven patients with hypertension and normal lipid were randomly divided into a treatment group of 34 patients and a control group of 33 cases. Two groups were given anti-hypertensive drugs. The treatment group received fluvastatin（40 mg/d）, and pla- cebo were given instead of real medicine to the control group. Before treatment and after 12 weeks of treatment, checked blood pressure, height, weight, heart rate, blood lipids,liver and kidney function, arterial endothelial function parameters including en- dothelin -1 （ ET-1 ） and nitric oxide （NO）, ankle-brachial index （ABI） brachial artery diameter （D） and blood flow speed （ V）, the main artery elasticity index （C1） and small artery elasticity index （C2）, calculated brachial artery diameter change rate （FMD）. Results：Compared with the control group,systolic pressure and pulse pressure and ET-1 of the treatment group were significantly reduced. But FMD and NO in the treatment group were significantly higher than that in the control group. Conclu- sion ： Fluvastatin can reduce the systolic and pulse pressure of hypertensives without hyperlipemia. If plus statins to hypertensive with conventional therapy, whose functionality and flexibility of the intravascular can be improved.