长效支气管扩张剂盐酸奥达特罗

Olodaterol hydrochloride, a long-acting bronchodilator

盐酸奥达特罗是一种新型选择性速效、长效β2-肾上腺能受体激动剂,可迅速起效且维持24h的支气管扩张作用,全身性副作用很少。由于只需每天用药1次,故能提高患者的依从性,给以气道阻塞为特征的疾病治疗提供一种新的治疗选择。本文介绍盐酸奥达特罗的药理作用、临床研究、不良反应和与其他药物联合治疗的研究情况。

Olodaterol hydrochloride is a novel, selective, long-acting β2-adrenoceptor agonist. It has a rapid onset of action and 24-hour bronchodilator efficacy with minimal systemic pharmacodynamic effects. Since allowing once-daily administration, olodaterol hydrochloride shows an improved effect in patient compliance and provides a new choice for the treatment of obstructive pulmonary diseases. This review introduces the pharmacological action, clinical studies, adverse reaction and the combination treatments with other drugs of olodaterol hydrochloride.