摘要
六水合三氯化铁催化下,β-酮酸酯、芳香醛、脲(1:1:1.5)在无水乙醇中进行环化缩合反应,合成了3,4-二氢嘧啶-2-酮衍生物,改进了Biginelli用盐酸为催化剂的一锅法反应,缩短了反应时间,操作简便,产率高达80%~90%,且Fe^(3+)对环境友好。
The syntheses of dihydropyrimidinones by a one - pot cyclocondensation of aldehydes,B - keto ester, and ureas ( 1 : 1 : 1 . 5 ) using ferric chloride hexahydrate as catalyst and alcohol as solvent are presented . The modified one - pot Biginelli's cyclocondensation not only features short reaction period, simple operation and high yield (80% -90%), but also is environment friendly.
出处
《有机化学》
SCIE
CAS
CSCD
北大核心
2000年第5期815-818,共4页
Chinese Journal of Organic Chemistry
基金
西北大学科研基金(98NW07F)
关键词
3
4-二氢嘧啶-2-酮
三氯化铁
一锅法
催化合成
Biginelli reaction, dihydropyrimidine - 2( 1H)- ones, ferric chloride hexahydrate , one - pot process