三氯化铁催化的—锅法合成3,4-二氢嘧啶-2-酮

A Novel One - Pot Synthesis of 3,4 - Dihydropyrimidine - 2(1H) -Ones by Catalyzed Ferric Chloride Hexahydrate

六水合三氯化铁催化下,β-酮酸酯、芳香醛、脲(1:1:1.5)在无水乙醇中进行环化缩合反应,合成了3,4-二氢嘧啶-2-酮衍生物,改进了Biginelli用盐酸为催化剂的一锅法反应,缩短了反应时间,操作简便,产率高达80％～90％,且Fe^(3+)对环境友好。

The syntheses of dihydropyrimidinones by a one - pot cyclocondensation of aldehydes,B - keto ester, and ureas ( 1 : 1 : 1 . 5 ) using ferric chloride hexahydrate as catalyst and alcohol as solvent are presented . The modified one - pot Biginelli's cyclocondensation not only features short reaction period, simple operation and high yield (80% -90%), but also is environment friendly.