磺胺甲噁唑的二阶导数差示脉冲极谱法测定

Quantitative Determination of Sulfamethoxazole by Second Derivative Differential Pulse Polarography

建立了磺胺甲噁唑的二阶导数差示脉冲极谱定量分析方法，磺胺甲噁唑在１０％ ＨＣｌ－（硼酸－氧化钾缓冲溶液）－水（５：５：９０）的底液中，于－１．４５Ｖ（ｖｓ．Ａｇ／ＡｇＣｌ）处出现一良好的 二阶导数差示脉冲极谱峰，磺胺甲噁唑浓度与其峰高在０．０８～０．８０ｍｍｏｌ／Ｌ范围内呈线性关 系（ｐ＜ ０．０１），检测限为 ８．６ｎｍｏｌ／Ｌ。本法简便、快速、灵敏，结果准确。

The second derivative differential pulse polarography was developed for the determination of the sulfamethoxazole and its preparation . In 10% HCl-buffer solution of boric acid-potassium chloride- water (5: 5: 90) solution, a good second derivative differential pulse polarographic peak appeared at -1.450 V(vs. Ag/AgCl). The linear relationship between concentration of sulfamethoxazole and peak height was obtained in the concentration range of 0.08 - 0.80 mmol/L (p<0.01). The detection limit is 8.6 nmol/L. The method is simple, rapid, sensitive. The results are accurate.