手性气相色谱分离α-醇腈和α-羟基酸对映体

Enantiomeric Separation of Cyanohydrins and α- Hydroxyl Acids by Chiral Gas Chromatography

以 3-丙酰基 - 2 ,6- O-二戊基 -γ-环糊精和 3-三氟乙酰基 - 2 ,6- O-二戊基 -γ-环糊精为手性固定相 ,利用气相色谱进行了 α-醇腈化合物、α-羟基酸以及二者共存时的对映体分离。系统观察了影响对映体分离的主要因素 ,优化了十种 α-醇腈和七种α-羟基酸拆分条件 ,3-三氟乙酰基 - 2 ,6- O-二戊基 -γ-环糊精毛细管柱的分离因子达到 1 .0 5～ 3.1 2 ,对 α-醇腈的拆分效果优于对应的 α-羟基酸 。

A method for simultaneous or respective seperation of enantiomers of cyanohydrins and α hydroxyl acids was established by gas chromatography with two chiral solid phases, 2,6 di pentyl 3 trifluoroacetyl γ cyclodextrin (G TA) and 2,6 di pentyl 3 propionyl γ cyclodextrin(G PN). The enantiomers of 10 cyanohydrins and 7 α hydroxyl acids were entirely separated on G TA column ( α =1.05～3.12),better than on G PN column. The main factors to influence the separation and the chiral recognition mechanism were also discussed.