抗凋亡蛋白B淋巴细胞／白血病-xL的表达在前列腺增生衰老逃逸机制中的作用

Implication of anti-apoptotic protein B lymphocytes/leukemia-xL expression in aging escape mecha- nism of benign prostatic hyperplasia

目的探讨抗凋亡蛋白B淋巴细胞／白血病-xL（bcl-xL）在良性前列腺增生（BPH）发病机制中的作用及其与临床指标的关系。方法采用免疫组织化学法检测bcl-xL和雄激素受体（AR）在30例BPH和16例正常前列腺标本（正常对照组）中的表达；用等级相关分析方法分析bcl-xL与临床数据的关系。结果bcl-xL和AR在BPH组中的表达分别为7．982±2．542和9．837±3．493，在正常对照组的表达分别为3．991±0．508和7．328±0．612，BPH组的表达量明显高于正常对照组（P〈0．05）；在BPH组30例患者中bcl-xL与AR的表达采用Spearman等级相关系数分析结果（r=0．540，P〈0．01），两者呈正相关（P〈0．05）；此外，bcl-xL的表达与BPH患者的年龄、前列腺体积及前列腺特异抗原（PSA）值相关系数分别为0．712、0．684和0．379，均呈正相关（P〈0．05）。结论bcl-xL在良性前列腺增生衰老逃逸发病机制中可能具有重要作用，并且与BPH的进展明显相关。

Objective To study the effects of antiapoptotic protein B lymphocytes/leukemia-xL （bcl-xL） on benign prostatic hyperplasia （BPH） pathogenesis and their relationship to the clinical indica- tors. Methods The expression of bcl-xL and androgen receptor （AR） in 30 BPH tissues and 16 normal prostatic tissues was detected by using immunohistochemistry. The relationship between bcl-xL and clinical indicators was analyzed by Spearman correlation test. Results As compared with normal prostatic tissues （3.991 ± 0. 508 and 7. 328 ± 0. 612）, the expression of bel-xL and AR was significantly increased in BPH tissues （7.982±2. 542 and 9. 837 ±3.493, P 〈 0.05 ）, and there was a positive correlation （0. 540, P 〈 0.01 ） between the expression of bcl-xL and AR in BPH. In addition, the expression of bcl-xL had a posi- tive correlation with patients＇ age, prostate volume and PSA with the correlation coefficient being 0. 712, 0. 684 and 0. 379 respectively （P 〈 0. 05 ）. Conclusion bcl-xL may play an important role in aging escape mechanism of BPH and have certain relevance with the progress of BPH.