儿童急性下呼吸道感染肺炎链球菌抗体检测的研究

Invasive streptococcus pneumoniae infections in children with acute lower respiratory tract infections.

目的 探讨肺炎链球菌在儿童急性下呼吸道感染 (ALRI)中的地位 ,并比较多种抗体检测方法在诊断肺炎链球菌感染中的作用。方法 通过配对血清及循环免疫复合物使用EIA方法对 10 1例ALRI患儿进行肺炎链球菌抗体检测。结果 10 1例ALRI患儿中 ,肺炎链球菌感染 17例 (16 8% ) ,其中从血清中检测抗体 ,9例(8 9% )阳性 ,从循环免疫复合物中检测抗体 12例 (11 9% )阳性。结论 肺炎链球菌是儿童ALRI的常见病原。从循环免疫复合物中检测肺炎链球菌抗体的敏感性优于从血清检测抗体 ,由于两者存在无重叠部分 ,应联合使用 。

Objective To investigate the invasive streptococcus pneumoniae infections in child acute lower respiratory tract infections(ALRI) and to evaluate the roles of different antibody assays in diagnosis of streptococcus pneumoniae infections.Methods Streptococcus pneumoniae antibody was detected from the paired sera and the isolated immune complexes by means of EIA in the 101 children with ALRI.Results Streptococcus pneumoniae infections were found in 17(16 8%) out of 101 children with ALRI.9 cases(8 9%) were found in the serum,and 12 cases(11 9%) in immune complexes.Conclusion Streptococcus pneumoniae infection was common in children with ALRI.Detecting streptococcus pneumoniae antibody from the isolated immune complexs was more sensitive than from the paired sera.Because the two methods didn't accord with each other completely,the combining detection of the 2 methods was detected.