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蛋白质α-N-末端乙酰化修饰研究进展

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摘要 α-N-末端乙酰化修饰(α-N-terminal acetylation)是一种蛋白质 N-末端的修饰形式,是真核生物中最为普遍的蛋白质修饰方式之一。虽然α-N-末端乙酰化修饰早在20世纪70年代就被科学家所发现,但是到目前为止,其广泛存在的意义仍未有定论。近年来,研究人员发现了α-N-末端乙酰化修饰发生的规律,总结出了(X)PX 法则,探明了α-N-末端乙酰化修饰对多种蛋白质起着特异性的重要作用,使得人们更加清楚地了解细胞内一些生化反应发生的原理以及不同细胞通路的调节方式。此外,α-N-末端乙酰化蛋白质的序列检测方法也是近年来研究的热点之一。本文简要综述α-N-末端乙酰化修饰的研究进展。
作者 黄忱 陈建华
出处 《中国医药生物技术》 2013年第4期299-302,共4页 Chinese Medicinal Biotechnology
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参考文献20

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