摘要
目的探讨胃癌与微卫星不稳定(MSI)的关系。方法查阅国内外相关文献并进行综述。结果 MSI系碱基错配修复系统(MMR)缺陷导致的复制错误;MSI胃癌具有特征性的临床病理学及预后,可通过检测癌前组织以及胃癌组织中的MSI来评估胃癌发生风险和预后;MSI包括核基因MSI(nMSI)和线粒体MSI(mtMSI)。结论MSI在胃癌的发生和发展中起着重要的作用,其可能成为预测癌前病变癌变风险和胃癌临床预后的重要指标。
Objective To explore the relationship between microsatellite instability（MSI）and gastric cancer.Methods The related literatures at home and abroad were consulted and reviewed.Results The MSI is the replication errors caused by mismatch repair system defects.Gastric cancer which exhibiting MSI has characteris clinicopathological feature and prognosis.Detection the MSI of precancerous lesions and gastric cancer tissues can evaluate the risk and prognosis of gastric cancer.MSI include nuclear microsatellite stability（nMSI）and mitochondrial microsatellite instability（mtMSI）.Conclusions MSI plays an important role in the occurrence and development of gastric cancer.MSI may become a important indicator to forecast precancerosis risks and clinical prognosis of gastric cancer.
出处
《中国普外基础与临床杂志》
CAS
2013年第7期826-831,共6页
Chinese Journal of Bases and Clinics In General Surgery
关键词
胃癌
微卫星不稳定
线粒体微卫星不稳定
Gastric cancer
Microsatellite instability
Mitochondrial microsatellite instability
