摘要
背景与目的:卵巢甲状腺肿是一种少见肿瘤,尤其伴有卵巢外播散的更为少见。本研究旨在探讨卵巢甲状腺肿的临床及病理组织学特征、诊断及鉴别诊断。方法:观察14例良、恶性卵巢甲状腺肿的临床及病理学特征,行免疫组化EnVision法染色,PCR—DNA检测,同时复习相关文献。结果:14例良、恶性卵巢甲状腺肿患者平均年龄45.6岁(18-71岁),以盆腔肿物为主要临床表现。其中12例为卵巢甲状腺肿,镜下主要由增生的甲状腺组织构成;1例为恶性卵巢甲状腺肿,镜下呈甲状腺乳头状癌表现;1例来源于卵巢甲状腺肿的高分化滤泡癌(highly differentiated follicular carcinoma of ovarianorigin,HDFCO),镜下组织学呈良性但生物学呈恶性表现。结论:卵巢甲状腺肿是少见的单胚层畸胎瘤,恶变率低,尤其是超出卵巢病变已有播散而镜下组织学呈良性的卵巢甲状腺肿发病率更低,具有较独特的临床病理学特征。良、恶性卵巢甲状腺肿预后均较好,需与颗粒细胞瘤、类癌鉴别。
Background and purpose: Struma ovarii is a rare tumor, especially with extraovarian spreading. The study aimed to investigate the clinical and pathological features, diagnosis and differential diagnosis of ovarian goiter. Methods: Clinical and pathological features of 14 cases of benign and malignant ovarian goiter were observed. Immunohistochemical EnVision staining, PCR-DNA sequencing and review of related literature were also used. Results: In 14 cases of benign and malignant ovarian goiter, the average age of onset is 45.6 years (18-71 years old), and pelvic ~mor is the main clinical manifestation. According to the related literature of diagnostic criteria, 12 cases are stnmaa ovarii, which is consisted ofhyperplasia of the thyroid tissue under microscopic examination, 1 case is malignant struma ovarii, which is papillary thyroid carcinoma by microscopic presentation, and 1 case is highly differentiated follicular carcinoma of ovarian origin (HDFCO), which is histological benign by microscopic presentation, but is malignant by biological behavior. Conclusion: Struma ovarii is a rare ovarian mondemal teratoma, with low rate of malignant change and beyond ovarian lesions disseminated microscopic histological benign struma ovarii is lower incidence, which has unique clinical and pathological features. Comprehensively considering the related literatures, this study indicates that the disease is in accordance with HDFCO. Struma ovarii prognosis is good, and should be differentiated from carcinoid and granular cell tumor.
出处
《中国癌症杂志》
CAS
CSCD
北大核心
2013年第7期524-529,共6页
China Oncology
基金
新疆维吾尔自治区科技支撑计划(No:201233142)