基因重组间充质干细胞作为肿瘤靶向细胞载体的研究进展

Research progress of gene recombinant mesenchymal stem cells as tumor targeting delivery vehicles

近年来,基因肿瘤靶向传递系统受到广泛关注。通过这一靶向传递系统可以提高治疗基因对肿瘤组织的选择性,进而提高基因治疗的成功率和减少相应的副作用等。因此,研究设计新型基因靶向传递载体已成为当前的研究热点。研究表明,间充质干细胞(MSCs)具有向肿瘤部位迁移的能力,这使得MSCs有望成为一种全新而高效的肿瘤靶向传递载体。本文对MSCs作为一种肿瘤基因治疗靶向载体的可行性进行了综述,并提出了有关这方面基因治疗的挑战和思考。

The applications of targeting gene delivery systems in tumor therapy have attracted extensive attention of researchers in recent years, as they can selectively deliver the therapeutic gene to tumor sites, improve the success rate of gene therapy and reduce the side effects. Therefore, design and development of novel gene delivery vehicles have been a hot area of current research. Recent studies have shown that mesenchymal stem cells （MSCs） have the ability to migrate towards and engraft into the tumor sites. Therefore, these properties make them a great hope for efficient targeted-delivery vehicles in cancer gene therapy. In this review, we examine the promising of utilization of MSCs as a targeted-delivery vehicle for cancer gene therapy, and summarize various challenges and concerns regarding this therapy.