干细胞治疗终末期肝病的进展与挑战

Progress and challenge in the treatment of end-stage liver disease with stem cells

干细胞包括胚胎干细胞和成体干细胞,具有无限自我更新能力,可以分化成特定组织,修复各种损伤。骨髓是成体干细胞的重要来源,主要含骨髓造血干细胞和间充质干细胞。目前利用干细胞治疗终末期肝病越来越受到关注。本文从体外、动物实验和临床研究三个方面总结了干细胞特别是成体干细胞治疗终末期肝病的研究进展,重点阐述各种来源干细胞在临床应用中取得的进展,探讨干细胞治疗终末期肝病的可能机制,提出目前研究存在的问题,展望未来的应用前景。

Stem cells,including embryonic stem cells and adult stem cells,are multipotent cells that have self-renewing abilities and the potential to diferentiate into various types of cells,and to repair various tissue damages.Bone marrow is the major source of adult stem cells,including mainly the bone marrow hematopoietic stem cells and mesenchymal stem cells.End-stage liver disease is a serious clinical systemic syndrome,and the use of stem cells in the treatment of end-stage liver disease has received more and more atention.his review summarizes the research progresses of stem cells,especially adult stem cells,in respect of the treatment of end-stage liver disease in the form of in vitro study,animal experimentation and clinical research,with emphasis on the research progress in the use of stem cells of various sources in clinical application,discussion of possible mechanisms of stem cell therapy for end-stage liver disease,to point out the problems existing in current research,and to look forward to the prospect of future application.