医用海藻酸基生物材料的研究进展

PROGRESS OF ALGINATE-BASED BIOMEDICAL MATERIALS

目的分析医用海藻酸基生物材料的研究现况,重点介绍其在临床领域的应用策略及研究进展,并讨论该材料在临床应用中需关注的重点问题。方法基于对国内外医用海藻酸基生物材料研究的广泛调研,并对国内外相关专利、文献、医药制品进行检索,综合分析其研发、应用现况,提出应重点关注的几个研究方向。结果医用海藻酸基生物材料已在临床广泛应用,知识产权方面也有多项专利,但集中于创伤敷料和齿科印模领域。心衰治疗、栓塞术、组织工程和干细胞培养作为较新的研究点有望成为该领域的发展新方向。结论医用海藻酸基生物材料新产品的开发具有良好的临床可行性和必要性,但作为新策略、新产品尚需进行大量的应用基础研究。

Objective To review the current situation of alginate-based biomedical materials,especially focus on the clinical strategies and research progress in the clinical applications and point out several key issues that should be concerned about. Methods Based on extensive investigation of domestic and foreign alginate-based biomedical materials research and related patent,literature,and medicine producted,the paper presented the comprehensive analysis of its research and development,application status,and then put forward several new research directions which should be focused on. Results Alginate-based biomedical materials have been widely used in clinical field with a number of patients,but mainly in the fields of wound dressings and dental impression.Heart failure treatment,embolization,tissue engineering,and stem cells culture are expected to become new directions of research and products development. Conclusion Development of alginate-based new products has good clinical feasibility and necessity,but a lot of applied basic researches should be carried out in the further investigations.