新诊断2型糖尿病患者血清25-羟维生素D_3的临床意义

Clinical Significance of Serum 25-hydroxy Vitamin D_3 in Newly Diagnosed Type 2 Diabetes Mellitus

目的观察新诊断2型糖尿病(type 2 diabetes mellitus,T2DM)患者血清25-羟维生素D3[25-hydroxy vitamin D3,25(OH)D3]水平的变化,分析血清25(OH)D3在新诊断T2DM患者中的意义。方法通过比较118例新诊断T2DM患者与60例健康体检者血糖、血脂、胰岛素抵抗指数(homeostasis model assessment insulin resistance index,HOMA-IR)、胰岛β细胞功能指数(homeo-stasis model assessment isletβ-cell function index,HOMA-β)及25(OH)D3等方面的差别,并分析25(OH)D3与HOMA-IR、HOMA-β的相关性。结果 T2DM组患者血糖、血脂、HOMA-IR高于正常对照组(P<0.05),而HOMA-β、25(OH)D3低于正常对照组(P<0.05),Pearson相关分析显示T2DM组患者血清25(OH)D3与HOMA-IR呈负相关(r=-0.55,P均<0.05),与HOMA-β呈正相关(r=0.63,P<0.05)。结论新诊断T2DM患者血清25(OH)D3的缺乏与胰岛素抵抗和胰岛β细胞分泌功能下降有关。

Objective To investigate the changes of serum 25 - hydroxy vitamin D3in newly diagnosed type 2 diabetes mellitus,and analysis the significance of serum 25 - bydroxy vitamin D3 in newly diagnosed type 2 diabetes mellitus. Methods Totally 118 newly diag- nosed type 2 diabetes mellitus patients were compared with 60 healthy individuals in clinical characteristics including blood glucose, lipid profiles, insulin resistance index, islet β -cell function index and 25 -hydroxy vitamin D3. The correlation of 25 -hydroxy vitamin D3 with insulin resistance index, islet β -cell function index was analyzed. Results The type 2 diabetes mellitus patients showed higher level of blood glucose,lipid profiles and insulin resistance index than healthy individuals （ P 〈 0.05） , but lower level of isletβ - cell func- tion index ,25 -hydroxy vitamin D3than healthy individuals （P 〈 0.05 ）. Pearson correlation analysis showed that 25 -hydroxy vitamin D3 was positively associated with islet β -cell function index（ r = 0.63,P 〈 0.05 ） , and negative associated with insulin resistance index（ r = - 0.55,P all 〈 0.05）. Conclusion The shortage of 25 - hydroxy vitamin D3in newly diagnosed type 2 diabetes mellitus patients may be correlated with increased insulin resistance and decreased insulin secretion.