MDS1-EVI1基因多态性与鼻咽癌相关性研究

Correlation between MDS1-EVI1 Gene Polymorphism and Nasopharyngeal Carcinoma

目的探讨MDS1-EVI1基因SNP rs6774994多态性与云南鼻咽癌之间的相关性研究.方法采用TaqMan-PCR方法检测MDS1-EVI1基因rs6774994基因型与等位基因频率.结果 (1)鼻咽癌组和对照组MDS1-EVI1基因rs6774994各基因型(P=0.843)和等位基因频率(P=0.784)组间分布差异无统计学意义(P>0.05);(2)鼻咽癌患者MDS1-EVI1基因rs6774994,有家族遗传史患者GG基因型携带者高于无家族遗传史患者(P<0.01),且病理分化类型为非低分化鳞癌的患者GG基因型携带者高于低分化鳞癌患者(P<0.01).结论 MDS1-EVI1基因rs6774994可能不增加云南人罹患鼻咽癌的风险.MDS1-EVI1基因rs6774994GG等位基因可能与家族遗传史和病理分化类型有一定相关性.

Objective To investigate the correlation of MDS1-EVI1 gene polymorphism rs6774994 with nasopharyngeal carcinoma in Yunnan population. Methods The allele frequencies of the genotypes of rs6774994 were detected by utilizing real-time fluorescent PCR method based on TaqMan probe. Results （1） There was no significant difference in the genotypes （P = 0.843） and allele frequency （P = 0.784） of MDS1-EVI1 rs6774994 between the nasopharyngeal carcinoma group and the control group （P 〉 0.05） . 2） In nasopharyngeal carcinoma patients with MDS1-EVI1 rs6774994, the GG genotype of patients with a family history was significantly higher than that of patients with no family history （P 〈0.001） , and the GG genotype of patients with no poorly-differentiated squamous cell carcinoma was significantly higher than that of patients with poorly-differentiated squamous cell carcinoma （P 〈0.001） Conclusion MDS1-EVI1 rs6774994 may be not associated with nasopharyngeal carcinoma in Yunnan population. The GG alleles with MDS1-EVI1 rs6774994 may be related to family history of genetic and pathological differentiation type.