抗真菌抗生素414的化学结构

The chemical structure of antifungal antibiotic 414

七烯大环内酯抗生素 414是由球孢玫瑰紫链霉菌产生的抗真菌抗生素 ,用电喷雾电离质谱法(ESI- MS)、HPL C法和其它有机光谱法对抗生素 414和克念菌素 (candicidin,美国药典委员会标准品 )进行化学结构分析、比较 ,确定了抗生素 414的分子量并证实抗生素 414的主要成分与国外报道的克念菌素的主要成分为同一物质。

Heptaene macrolide antifungal antibiotic 414 was produced by S.globonoseoviolaceus n.sp, the chemical structure identification of antibiotic 414 and its comparison with candicidin (reference standard) were carried out by electron spray ionization mass spectrum (ESI MS), HPLC and other organic spectrometric methods. The molecular weight of antibiotic 414 was given and antibiotic 414 was proved identical with candicicin.