肝素辅助因子Ⅱ活性检测的临床意义

Clinical significance of plasma heparin cofactor Ⅱ activity in patients with preeclampsia,acute myocardial infarction,etc.

目的 :探讨几种和血栓有关的疾病中血浆肝素辅助因子 活性 (HC :a)的临床意义。方法 :采用酶联凝固分析法 (EL CA)检测了妊高征、肝硬化、肾衰血透、深静脉血栓形成 (DVT)及急性心肌梗塞 (AMI)病人的血浆HC :a水平。结果 :妊高征、肝硬化和肾衰血透病人血浆 HC :a水平下降 ,而 DVT和 AMI病人血浆 HC :a水平正常。结论 :妊高征病人血浆 HC :a水平下降并与病情严重程度相关 。

Objective:To investigate the clinical significance of plasma heparin cofactor Ⅱ activity(HCⅡ:a) in patients with preeclampsia,livercirrhosis,chronic renal failure undergoing regular hemodialysis,deep venous thrombosis(DVT) and acute myocardial infarction(AMI).Methods:The HCⅡ:a was measured by enzyme\|linked coagulation assay(ELCA). Results:Diminution of HCⅡ:a was observed in preeclampsia,liver cirrhosis and chronic renal failure undergoing regular hemodialysis but not in DVT and AMI.Conclusion:HCⅡ:a may indicates the severity of preeclampisa because it progressively reduces when the severity of preeclampsia increases. Author′s address Fujian Provincial Geriatric Hospital,Fuzhou,350003