结节性筋膜炎19例临床病理分析

Clinicopathology analysis of nodular fasciitis in 19 cases

目的探讨结节性筋膜炎(NF)的临床病理特点。方法观察19例NF病例的病理组织学特点,分析临床资料并文献复习。结果 NF多见于青壮年,好发于上肢前臂,临床表现:生长迅速,肿块小,质硬或韧,边界不清。组织学特征:增生的纤维母细胞/肌纤维母细胞呈车辐状、"C"形或"S"形;核分裂象易见,无病理性核分裂象;小裂隙形成;红细胞外渗、有少量炎细胞及丰富的新生毛细血管;黏液样基质。结论 NF是一种纤维母细胞/肌纤维母细胞增生性病变,诊断时应注意其临床、组织学特征,并掌握鉴别诊断,防止误诊。

Objective To investigate the clinicopathological features of nodular fasciitis （NF）. Methods The histopathology characteristics of NF in 19 cases were observed,and the clinical datas were analysed and literatures were reviewed. Results NF was more common in young adults and occurs mostly at forearm of the upper limb,and its clinical manifestations was growing fast,small lumps without clear boundary and the texture of lumps was hard or tough.Histologic features：the proliferative fibroblasts/myofibroblast showed rung appearance,＂C＂ or ＂S＂ shape;mitotic count were easy to be saw without pathologic mitotic count;small fissure formed;red blood cells extravasated and there was a small amount of inflammatory cells and rich newborn capillaries having myxoid stroma. Conclusion NF is a kind of proliferative lesions fibroblast/myofibroblast.To prevent misdiagnosis,its clinical and histologic features should be noticed and the differential diagnosis should be mastered at the time of diagnosis.