甘草提取物促进补骨脂中补骨脂素和异补骨脂素在鼻腔粘膜的吸收

Effect of the Extract of Root of Glycyrrhiza uralensis on the Absorption of Psoralen and Isopsoralen by Nasal Mucosa

目的 :研究甘草提取物对补骨脂中补骨脂素和异补骨脂素在大鼠鼻粘膜吸收的影响。方法 :建立大鼠鼻腔重循环模型 ,用 HPL C法测定加与不加甘草提取物的循环液中补骨脂素和异补骨脂素的含量变化。结果 :加甘草提取物后补骨脂素和异补骨脂素在鼻粘膜的吸收有显著增加 ,在起始阶段的增加速度尤其明显。结论 :在一定 p H条件下 。

Effects of the extract of root of Glycyrrhiza uralensis Fisch.(GE) on nasal absorption of psoralen and isopsoralen isolated from the fruit of Psoralea corylifolia Linn. was studied on rat in situ nasal recirculation model. Change of psoralen and isopsoralen contents in the circulatory fluid was determined by HPLC after drug administration with or without the addition of GE. Results showed that there was a dramatic increase of both psoralen and isopsoralen absorption after GE supplement, especially in the initial stage of drug administration. It was concluded that GE could accelerate nasal absorption of psoralen and ispsoralen under appropriate pH condition.