摘要
目的探讨miRNA在胰腺癌患者血浆中的表达及临床意义。方法比较40例胰腺癌患者(观察组)及40例正常志愿者(对照组)血浆中的4种miRNA(miR-190、miR-196a、miR-221和miR-222)水平,并分析其与患者年龄、性别、肿瘤部位、分化程度及CA199水平的关系。结果胰腺癌患者血浆中4种miRNA表达量的水平较对照组均明显升高,差异有统计学意义(P<0.05)。胰腺癌患者血浆中miR-196a的高表达与胰腺癌的分期呈正相关(P<0.05),与其他因素无关。其他3种miRNA的表达与以上因素均无关,而且4种miRNA的表达量与血清中CA199无明显相关性(P>0.05)。结论 miRNA作为敏感而特异的胰腺癌肿瘤标志值得进一步研究。
Objective To study the expression expression and clinical significance of miRNA in plasma of patients with pancreatic cancer. Methods 40 patients with pancreatic cancer and 40 cases of normal group were compared in four kinds miRNA level（miR-190, miR-196a, miR-221, miR-222）, and analyzed the relationship between four kinds miRNA level and the patients＂ age,sex,tumor site,degree of differentiation and the level of CA199. Results miRNA expression level of four kinds with pancreatic cancer compared to control group having significantly higher,the differ- ence was statistically significant （P〈0.05）. In pancreatic cancer patients,miR-196a high expression was positively as- sociated with pancreatic cancer staging （P〈0.05）, had nothing to do with other factors. Other 3 miRNA expression had nothing to do with the above factors, and the expression quantity of four kinds had no significant correlation with serum CA199 （P〉0.05）. Conclusion miRNA as sensitive and specific marker of pancreatic tumor deserves further study.
出处
《中国实验诊断学》
2013年第7期1246-1248,共3页
Chinese Journal of Laboratory Diagnosis
