人体皮下脂肪和内脏脂肪在内分泌代谢方面的差异研究进展

Research Progress of Endocrine and Metabolic Differences between Subcutaneous and Visceral Adipose Tissue

肥胖的患病率在逐年升高,根据体内脂肪堆积部位的不同可分为腹型肥胖和周围型肥胖。研究发现,腹型肥胖者罹患糖尿病、心血管疾病的风险要高于周围型肥胖者。人体的内脏脂肪拥有更丰富的血流和神经分布,具有更高的细胞代谢活性,而且对人体激素的反应更敏感,输出更多的脂肪因子和游离脂肪酸,导致其与代谢疾病的发病风险关联性更高。

The incidence of obesity is increasing year by year.According to the body fat distribution,obesity can be classified into abdominal and peripheral obesity.Abdominal obesity carries greater risk of developing diabetes and cardiovascular diseases.The visceral adipose tissue has more distribution of blood and nerves,with higher cellular metabolic activity and higher sensitivity to human hormones,which expresses more adipokines and free fatty acids,and results in itscloser correlation with metabolic disease risks.Here is to make a review of the progress in differential research of subcutaneous adipose tissue and visceral adipose tissue from the perspectives of anatology,molecular and metabolisms.