脱钙骨基质的临床应用与研究进展

Clinical Application and Research Progress of Demineralized Bone Matrix

脱钙骨基质是一种具有骨传导和骨诱导性质的生物材料,以多种形式应用于临床治疗四肢长骨骨缺损,并取得了令人满意的效果。脱钙骨基质是由胶原蛋白、非胶原蛋白以及较低浓度的生长因子(如骨形态发生蛋白)等组成的复合物,具有良好的生物学特性、骨诱导及骨传导活性,可生物降解,促进新骨形成及骨组织矿化,加速骨愈合,是骨组织工程比较理想的支架材料,可以单独或者与自体骨及其他生物材料或者生长因子联合运用有效修复骨缺损。

Demineralized bone matrix（DBM） is an osteoconductive and osteoinductive biomaterial and approved medical device used in bone defects with a long track record of clinical use in diverse forms.DBM retains collagen proteins,non-collagen proteins and growth factors of low concentration,such as BMP.DBM provides a degradable matrix facilitating endogenous release of these compounds to the bone wound sites where it is surgically placed to ll bone defects,inducing new bone formation and accelerating healing.DBM is the ideal scaffold material for bone tissue engineering,alone or in combination with autologous bone or growth factors for bone defects repairing.