乙型肝炎病毒相关性肾炎发病机制的研究进展

Research Progress in Pathogenesis of Hepatitis B Virus Associated Nephritis

乙型肝炎病毒相关性肾炎(HBV-GN)是指由HBV感染引起的肾小球疾病,是我国常见的继发性肾小球肾炎,多发于儿童及青年人。但并非所有被HBV感染的个体均有肾脏受累。在儿童患者中,随着免疫系统的健全,HBV-GN有一定的自发缓解率,并维持肾功能正常,但仍有部分患者的临床症状持续存在,部分甚至进展为慢性肾功能不全。目前对HBV-GN的发病机制尚未完全明确。因此,针对该病的发病机制进行深入研究以指导临床合理有效地治疗是非常必要的。

Hepatitis B virus associated nephritis（HBV-GN） is a kind of glomerular disease caused by hepatitis B virus,which is a common secondary glomerulonephritis in China,mostly seen in children and young adults.However,not everybody who is infected with HBV has renal involvement.In children patients,with the immune system improving,HBV-GN has certain spontaneous remission rate,and maintains normal renal function.But a part of patients＇ clinical symptoms still persist,some even progress into chronic renal insufficiency.The pathogenesis of HBV-GN has not yet been understood completely.Therefore,the in-depth research of the pathogenesis of HBV-GN to guide clinical effective therapy is very necessary.