多发性骨髓瘤的流式细胞免疫表型研究进展

Research Progress in Flow Cytometric Immunophenotyping of Multiple Myeloma

尽管多发性骨髓瘤(MM)患者经治疗后能达到完全缓解,但大部分患者最终会复发。复发的根源在于体内残留有少量的MM细胞。为更早地监测MM复发,提高患者的生活质量,目前已有多种检测方法应用于临床,监测疾病的状态,其中多参数流式细胞仪在血液病检测中的价值已被越来越多的学者认同。为了更好地了解MM这一恶性血液病,更好地指导临床实践,对MM细胞的流式细胞免疫表型(FCI)研究进展予以综述。

Although patients with multiple myeloma can achieve complete remission after therapy,most of them will finally relapse.The root cause of the relapse is the existence of a few residual myeloma cells in vivo.For earlier monitoring recurrence of the disease and improving the quality of their life,a variety of detection methods can be applied to monitor the disease status in clinical work.More and more researchers know that multi-parametric flow cytometry is valuable in detecting hematological malignancies.In order to better understand multiple myeloma of the hematological malignancies and guide clinical practice,here is to make a review of the development of flow cytometric immunophenotyping（FCI） of multiple myeloma.