解毒理气活血汤治疗慢性乙型病毒性肝炎86例临床研究

Clinical investigation of chronic viral hepatitis B treated by Jieduliqihuoxue decoction

目的观察解毒理气活血汤治疗慢性乙型病毒性肝炎临床疗效。方法将172例慢性乙型病毒性肝炎患者随机分为2组。治疗组86例予解毒理气活血汤治疗,对照组86例用核苷类药物治疗。2组均3个月为1个疗程,4个疗程后统计疗效,并观察2组治疗前后肝功能[丙氨酸氨基转移酶(ALT)、天冬氨酸氨基转移酶、γ-谷氨酰转肽酶(γ-GT)]及肝纤维化指标[透明质酸(HA)、Ⅲ型前胶原(PCⅢ)、Ⅳ型胶原(CⅣ)、层粘连蛋白(LN)]情况。结果治疗组显效率74.42%,对照组显效率37.21%,2组比较差异有统计学意义(P<0.05),治疗组疗效优于对照组。2组治疗后ALT、AST及γ-GT与本组治疗前比较差异有统计学意义(P<0.01),2组治疗后均降低;2组治疗后ALT、AST及γ-GT比较差异无统计学意义(P>0.05),2组间对肝功能恢复疗效相差不大。2组治疗后HA、PCⅢ、CⅣ及LN与本组治疗前比较差异均有统计学意义(P<0.01),2组治疗后均降低;2组治疗后HA、PCⅢ、CⅣ及LN比较差异均有统计学意义(P<0.05),治疗组控制肝纤维化疗效优于对照组。结论解毒理气活血汤治疗慢性乙型病毒性肝炎有显著的治疗作用。

Objective To investigate the effect of chronic viral hepatitis B treated by Jieduliqihuoxue decoction.Methods 172 patients with chronic viral hepatitis B were randomly divided into two groups.Treatment group（n = 86） received Jieduliqihuoxue decoction.Control group（n = 86） received nucleoside anologues.The course was three months in two groups.The results were analyzed after four courses.The changes of ALT,AST,γ-GT,HA,PC Ⅲ,CⅣ and LN before and after treatment were observed.Results Efficiency of the treatment group was 74.42%,the efficiency of the control group was 37.21%.There was significant difference between two groups（P 〈0.05）.There were significant differences between before and after treatment on ALT,AST and γ-GT in two groups（P 〈0.01）.The levels of ALT,AST and γ-GT after treatment were decreased.There was no difference between two groups（P 〈0.05）.There were significant differences between before and after treatment on HA,PCⅢ,CⅣ and LN in two groups（P 〈0.01）.The levels of HA,PCⅢ,CⅣ and LN after treatment were decreased.There was significant difference between two groups on HA,PCⅢ,CⅣ and LN after treatment（P 〈0.05）.Conclusion Jieduliqihuoxue decoction has a significant therapeutic effect on chronic viral hepatitis B.