血清生长激素释放肽水平与早产儿喂养不耐受相关性研究

Study on the relationship between serum growth hormone releasing peptide and feeding intolerance in premature infants

目的测定早产儿生后24 h内血清生长激素释放肽(Ghrelin)水平,探讨其与早产儿喂养不耐受的相关性。方法选取2012年5月至2012年10月生后24 h内入住安徽医科大学第一附属医院新生儿科无伴发疾病的早产儿52例(年龄<24 h)作为研究对象,采用ELISA法测定生后24 h内的血清Ghrelin水平,同时记录其喂养情况,根据是否发生喂养不耐受分为喂养不耐受组(24例)与无喂养不耐受组(28例)两组,比较两组血清Ghrelin水平。结果喂养不耐受组生后24h内血清Ghrelin水平明显低于无喂养不耐受组,差异有统计学意义[(604.79±28.07)pg/ml vs(650.75±34.34)pg/ml,P<0.05]。结论血清Ghrelin水平与早产儿喂养不耐受发生有关,早期检测血清Ghrelin水平对预测早产儿喂养不耐受有一定价值;外源性Ghrelin可能具有改善早产儿肠内喂养耐受性的作用。

Objective To study the relationship between serum growth hormone releasing peptide and feeding intolerance in prema- ture infant. Methods 52 preterm infants who were admitted to our hospital from 2012.5 to 2012.10 were divided into two groups, feeding intolerance group （24 premature infants） and non -feeding intolerance group （28 premature infants）. Serum growth hormone releasing pep- tide（ghrelin） concentrations were measured by ELISA in 24 hours after birth in the two groups. Results The level of serum ghrelin in 24h after birth in feeding intolerance group was significantly lower than that in non -feeding intolerance group（ 604.79±28.07 pg·ml^-1 vs 650. 75±34.34 pg·ml^-1 ） （ p 〈 0.05 ） . Conclusion The level of serum Ghrelin is related to feeding intolerance in premature infant. To detect serum Ghrelin early might be valuable to predict feeding intolerance in premature infant. Ghrelin might play a role in improve feeding intoler- ance in premature infant.