紫杉醇引起关节肌肉痛及消炎痛栓缓解其疼痛的疗效观察

The observation of adverse reactions about paclitaxel on joint and muscle pain and observation indomethacin suppository treatment the effect of pain

目的观察紫杉醇(paclitaxel,PTX)化疗所致的关节、肌肉痛的不良反应及消炎痛栓缓解其疼痛的临床疗效。方法本组随机选取使用紫杉醇辅助化疗50例非小细胞肺癌患者,观察每周期化疗过程中出现关节、肌肉痛的不良反应,以及使用消炎痛栓后疼痛控制情况。结果 34例患者在化疗中出现不同程度的关节、肌肉痛。19例为轻度疼痛,未镇痛处理;14例出现中度疼痛,予消炎痛栓纳肛后,12例疼痛缓解,另外2例缓解不理想,予口服吗啡后缓解;1例出现较严重的关节、肌肉痛,口服吗啡后缓解。结论应用紫杉醇化疗后,关节、肌肉痛症状常见,消炎痛栓纳肛可以缓解其疼痛。

Objective To observe the adverse reactions about joint and muscle pain of paclitaxel chemotherapy and the clinical effi- cacy of indomethacin suppository. Methods we observed 50 cases of lung non - small cell cancer after using paelitaxel chemotherapy, and found that each course of chemotherapy, appeared joint and muscle pain adverse reactions. Results 34 patients during chemotherapy ap- peared various degree of joint and muscle pain, 19 cases had mild pains, there is no need for clinical treatment;14 patients had moderate pain, 12 cases were put Indomethaein suppository, and released the symptoms. The left 2 were released by oral morphine. There is still 1 case who suffered severe pain and it was alleviated by oral morphine. Conclusion The application of paelitaxel chemotherapy will lead to joint and muscle pain symptoms. Indomethacin suppository can treat the paclitaxel chemotherapy joint pain and muscle aches.