7644例孕中期产前筛查及确诊检查结果分析

Analysis of prenatal screening and diagnosis test results in 7644 cases of second trimester of pregnancy

目的对孕中期胎儿进行唐氏综合征（DS）、神经管缺陷（NTD）和18-三体综合征的筛查和诊断，减少患儿的出生。方法对山东省滕州市妇幼保健院产科门诊7644例孕15～20周孕妇，用化学发光法进行血清生化标志物甲胎蛋白（AFP）、绒毛膜促性腺激素（HCG）及游离雌三醇（uE3）浓度检测，利用配套软件计算胎儿患DS、NTD和18-三体综合征的风险。结果筛查的7644例孕妇中，DS阳性421例，236例做确诊检查，阳性12例；NTD筛查阳性58例，5例确诊；18-三体综合征筛查阳性51例，35例做确诊检查，阳性1例。结论孕中期进行产前筛查，可减少缺陷患儿出生率，具有重要社会价值。

[ Objective ] To screen and diagnose Down＇s syndrome, neural tube defects and trisomy 18 syndrome during mid-term pregnancy to decreased the rate of birth defects. [ Methods ] 7644 women at 15-20 weeks gestation were screened by maternal serum AFP, β -hCG and uE3 using chemiluminescence, then to calculation the risk of fetal suffering from DS,NTD and trisomy 18 syndrome. [ Resluts ] Among the 7644 pregnant women, 421 were found to be at high risk with DS, by amniocentesis ,12 eases were diagnosed DS; 58 were found to be at high risk with NTD, by amniocentesis ,5 cases were diagnosed NTD; 51 were found to be at high risk with trisomy 18 syndrome, by amniocentesis ,1 cases were diagnosed trisomy 18 syndrome. [ Conclusions ] Prenatal screening and prenatal diagnosis decreased the rate of birth defects.They have distinct social benefit, they are very effective technical means to carry out our country＇s prepotency policy.