肾综合征出血热Ⅰ型灭活疫苗接种组和对照组定群血清流行病学研究

A Comparative Study on Antibody Levels of Vaccinated Group with Controlled Group Immunized with Type I Inactivated Vaccine against Hemorrhagic Fever with Renal Syndrome

为比较肾综合征出血热Ⅰ型灭活疫苗接种组和对照组免疫后 4年的抗体水平 ,1997年 11月～ 1998年 7月在浙江省建德市肾综合征出血热Ⅰ型灭活疫苗随机对照试验现场 ,分别采集接种组和对照组双份血清 2 95人和 2 68人 ,检测血清中间接荧光抗体。按血清间接荧光抗体阳性或阴性来比较接种组和对照组的抗体水平 ,均未见接种组和对照组有显著差异。接种组同对照组免疫后 4年抗体水平无显著性差异 ,未见肾综合征出血热Ⅰ型灭活疫苗增强接种人群发生隐性感染。

A comparative study on antibody levels of the vaccinated group with the controlled group was carried out in a randomized controlled field trial using type I inactivated vaccine against hemorrhagic fever with renal syndrome (HFRS) in Jiande county and the enhancement of subclinical infection by the vaccine was also surveyed. The paired sera from 295 vaccinated persons and 268 controlled persons who joined the field trial (Aug. 1994) in Jiande county were collected before immunization and four years later (Nov. 1997～July 1998). The anti HFRS antibody was detected by indirect immuno fluorescent assay(IFA). The results showed that by comparing HFRS antibody positive rates of the first sera of vaccinated group with that of the controlled group, there was no significant difference, the negative seroconversion rates were found the same in the two groups 4 years after immunization. There was no enhancement of subclinical infection found in vaccinated group.