黑龙江省婴幼儿b型流行性感冒嗜血杆菌多糖抗体水平监测

The Investigation on Seroepidemiology of Haemophilus Influenzae Type b in Heilongjiang Province

为了解黑龙江省婴幼儿b型流行性感冒 (流感 )嗜血杆菌 (Hib)的感染状况 ,对哈尔滨、大庆、齐齐哈尔、佳木斯、鸡西、牡丹江6个市的 0～ 48月龄婴幼儿共 3 0 0份血清 ,用放射免疫方法进行了流感嗜血杆菌多糖 (Hib -PRP)抗体水平的监测。结果显示 :该人群抗体阳性率平均为 42 0 0 % ,其中男性为 3 6 94% ,女性为 47 5 5 % ;Hib -PRP抗体几何平均滴度 (GMT)为 0 18μg/ml。Hib-PRP抗体的年龄别分布是 :出生后抗体稍高 ,4～ 6月龄降至最低 ,8月龄后抗体阳性率和GMT随年龄增长而逐渐增高。按城市分 ,Hib -PRP抗体阳性率和GMT最高的是哈尔滨 ,其次为大庆、鸡西、牡丹江 ,最低的是齐齐哈尔、佳木斯。按采样地可分为医院组、城镇组和农村组 ,婴幼儿Hib -PRP抗体水平以医院组的明显高于城镇组 ,城镇组明显高于农村组。

In order to study the status of Hib infection in Heilongjiang Province, 300 serum samples from children aged 0～48 months were collected from six districts that are Harbin, Daqing, QiQihar, Jiamusi, Jixi and Mudanjiang. The natural antibody level to Hib-PRP was measured with a radio immunoassay. The positive rate of anti Hib-PRP antibody was 42.00% in average in these children, 36.94% in male and 47.55% in female. The average GMT was 0.18 μg/ml. Comparison of antibody level of different age groups showed that children aged 0～4 months had higher antibody level, those aged 4～6 months had the lowest antibody level, and those over 8 months, with the increase of age, the antibody level was growing. The positive rate and antibody level was the highest in Harbin, the followed were Daqing, Jixi, Mudanjiang. The lowest were Qiqihar and Jiamusi. And we also found that antibody level of hospital group was higher than that of the town group, the town group was higher than that of rural group. The results provide a scientific basis for Hib immunization.