比索洛尔对急性心肌梗塞心率变异性的影响

Effect of Bisoprolol on Heart Rate Variability of Acute Myocardial Infarction

目的 观察比索洛尔对急性心肌梗塞 (AMI)心率变异性 (HRV)的影响。方法 将 50例AMI患者随机分成观察组和对照组各 2 5例 ,两组均采用相同的常规和急救用药 ,观察组加服比索洛尔 2 .5～ 5mg ,1日 1次。用 2 4h动态心电图 (含有HRV软件 ) ,进行心率 (HR)、相邻R -R间期 >50ms的百分比 (PNN50 )、变异系数 (CV)、低频带 (LF)、高频带 (HF)、低频 /高频 (LF/HF)的统计学分析。结果 观察组和对照组间HRV的HR、PNN 50、HF、LF/HF有显著性差异 (P <0 .0 5) ,CV、LF有极显著性差异 (P <0 .0 1) 。结论 HRV能被有关药物调整 ,可作为心脏性猝死的独立观察指标。

Objective To observe the effect of Bisoprolol on HRV(heart rate variability) of AMI (acute myocardial infarction).Methods 50 cases of AMI were classified as observation group and control group at random (n=25),and given the same routine and first-aid medicine.The observation group was added Bisoprolol in a dose of 2.5～5 mg once a day.24 hours dynamic electrocardiogram with the analysis software of HRV was used to analyse HR(hear rate)、percentage(PNN 50)between R-R and the period>50 ms、CV(coefficient of variation)、LF(low-frequency)、HF(high-frequency)、LF/HF.Results There was significant difference (P<0.05) in HR,PNN 50,HF and LF/HF of HRV between two groups,or there was very significant difference (P<0.01)  in CV and LF.Conclusion The results indicates that medicine can effect and regulate HRV.As an independent target,HRV can foresee SCD(suddenly circulation death). [