2H_3R_3Z_3S_3(E_3)/4H_3R_3方案治疗对乙肝病毒标志物阳性患者肝功能的影响

Effect of regimen of 2H_3R_3Z_3S_3(E_3)/4H_3R_3 on the liver function of the pulmonary tuberculosis patients with positive markers of viral hepatitis B

探讨 2H3R3Z3S3(E3) / 4H3R3方案治疗对合并乙型肝炎病毒标习物HBsAg(+)、HBeAb(+)、HBcAb(+)肺结核患者肝功能的影响。方法 回顾性分析 1994年 12月至 1998年 12月采用 2H3R3Z3S3(E3) / 4H3R3方案治疗的初治涂阳并乙肝标志物HBsAg(+)、HBeAg(+)、HBcAg(+)肺结核患者肝功能的情况。以同期采用同样方案治疗的乙肝标志物五项阴性肺结核患者为对照。结果 乙肝阳性组肝损率 (15.6 % )高于乙肝阴性组 (12 .0 % )。两组经统计学处理无显著性差异。 (P >0 .0 5)。结论 2H3R3Z3S3(E3) / 4H3R3方案治疗对合并乙肝病毒标志物HBsAg(+)、HBeAg(+)、HBcAg(+)肺结核患者肝功能损害小 ,值得推广。

Objective To investigate the effect of regimen of 2H 3R 3Z 3S 3(E 3)/4H 3R 3 on the liver function of the pulmonary tuberculosis patients accompanied with positive markers of HBsAg,HBeAb,and HBcAb.Methods From December 1994 to December 1998,the liver function of the pulmonary tuberculosis patients with positive markers of HBsAg,HBeAg,and HBcAb (group Ⅰ) who were given the treatment of regimen of 2H 3R 3Z 3S 3(E 3)/4H 3R 3,was retrospectively analyzed.Simultaneously,the results have been compared with those of negative markers of viral hepatitis patients (group Ⅱ).Results The incidence of liver damage in group Ⅰ was 15.6%,higher than that in the group Ⅱ (12.0%),but no significant difference was found between the two groups ( P >0.05).Conclusion The regimen of 2H 3R 3Z 3S 3(E 3)/4H 3R 3 had a slight damage to the liver function of the pulmonary tuberculosis patients with positive marker of HBsAg,HBeAb,and HBcAb and is worthy spreading.